At KD Pharma we use multiple state-of-the-art separation and purification technologies processes which are protected by numerous patents. These technologies allow for the production of pure molecules from natural products like fish, algae, and plant oils, as wells as from complex chemical mixtures. Our quality and purity is unsurpassed, and with concentrations as high as 99 % of a single fatty acid or phytochemical. Importantly, we can combine these with other technologies in our portfolio to help companies optimize their manufacturing process.
The main technology groups include:
kd-pür® Supercritical Fluid Chromatography (SFC). In the SFC process, the oil coming from the SFE process (Supercritical Fluid Extraction) is passed through a chromatographic column which is packed with a highly selective separation material. While passing through this column, the fatty acids get separated according to their size and degree of unsaturation. This allows the individual fractions, each enriched for with specific Omega-3’s or phytochemicals, to leave the column at separated intervals. Finally, the CO2 is released from the oil, allowing for an exceptionally high level of purity for the Omega-3 concentrates and plant extracts.
Unlike some other extraction methods, with kd-pür® technology, no chemical solvents, water, sugar, saturated fatty acids, cholesterol or proteins can be found in the finished oil.
kd-pür® Enhanced Silver Technology is a further development of the kd-pür® technology, where ultra-high concentrations of EPA, DHA, DPA and other specific Omega-3 components can be achieved. This technology uses the supercritical carbon dioxide method and also includes a silver-based extraction process.
With this technology, natural oils can be extracted to previously unheard-of levels of purity. Ultra-high levels of Omega-3 such as EPA, DHA, DPA, Omega-6, Omega-7, Omega-9 are made into very pure concentrates. Impurities are minimized to extremely low levels.
kd-pür® Simulated Moving Bed Technology (SMB) is a highly engineered process for implementing chromatographic separation. It is used to separate one chemical compound or one class of chemical compounds from one or more other chemical compounds based on their geometry and has advantages over using simple (batch) HPLC chromatography.
The technology allows the production of large quantities of highly purified material at a continuous and high rate of production, and decreases solvent and energy requirements. When combined with other KD Pharma technologies, SMB can produce extremely high concentrates of EPA, DHA, DPA and other specific Omega-3s. Additionally, this technology can be used for chiral separations of small molecule APIs.
kd-pür® Urea Precipitation Technology is a method used for the concentration and purification of compounds based on their solubilities. Urea precipitation of fatty acids has been extensively used for enriching omega-3 fatty acids. This method involves the formation of inclusion compounds between urea and fatty acids, which can then be separated based on their different solubilities. The urea adduction method is considered one of the most efficient techniques for concentration and purification of fatty acids.
